Economics of open-access publishing

October 24, 2011 § Leave a comment

Elsevier alone takes out of academia — not its turnover but its profits, which are given to shareholders who have nothing to do with scholarly work — is enough to fund every research article in every field in the world as open access at PLoS ONE’s rate.

A must read, here too. Via Hacker News.

Salts shaping ice crystals ?

October 19, 2011 § Leave a comment

Well, it looks like it, indeed. Today, we report in PLoS One some very intriguing results, which kept us busy for the last 3 years. I never worked so long on a topic before publishing a paper, by the way.

Okay, some feedback first. My main occupation is this ice-templating thing, using ice the growth of ice crystals to template the porosity in various materials (ceramics, mostly). One of the issue bugging us is that the growth of the ice crystals depends on (too) many parameters. Depending on what you put in your suspension and how you freeze it, you ends up with a variety of unpredictable morphologies. In an ideal world, you want to control the morphology of the ice crystals (and hence of the pores) independently of the other processing parameters, to make your work more predictable and reproducible. So you need to control ice crystals. Easier said than done, though. You need, for instance, a compound that will interact directly with the growing crystals, in order to precisely control the growth of the crystals at the atomic level. And your problems start here. Finding such compound is no easy task.

Many people are interested in controlling ice crystals growth, from engineers to biologists and the food processing industry (ice cream, yummy), to name a few.  A number of living organisms and creatures are also very interested in controlling the growth of ice crystals, such as fishes or insects. Such control is exerted through the so-called antifreeze proteins. A whole family of proteins which can prevent, slow down or retard the growth of ice crystals and thus avoid and/or limit the freezing induced damages. How these proteins interact with the ice crystals is still under debate, and is arguably one of the toughest recognition problem in biology, though it looks like an important part of the puzzle has been solved recently. Antifreeze proteins are nice, but awfully expensive and difficult to extract. Cheap and easily available synthetic compounds are therefore highly desirable. Synthetic compounds have been developed largely based on what we understand about antifreeze proteins. All substances known to date to interact with growing ice crystals have all been macromolecules – proteins, glycoproteins or polysaccharides.

What we’ve found, by complete accident of course, is that a simple salt (zirconium acetate) can exhibit such ice shaping properties. The ice crystals in presence of this salt adopt their equilibrium hexagonal structure. In ice-templated materials, this results in the formation of faceted, hexagonal pores, like the ones below, in comparison to the usual dendritic morphologies.

This is both remarkable and intriguing. Salts have never been shown to have an ice-shaping activity on their own. The ice shaping activity seems very similar to that of antifreeze proteins. We first discovered this three years ago, by accident. And as of today, we still have no explanations of the mechanism by which this salt is controlling the growth of the ice crystals. The safest bet would be the formation of an ice-interacting network, based on the association of the ionic complex formed in suspension by the salt. And yet, we have no clues of this happening so far. We hope that these results will prompt further work from other group to investigate this more thoroughly. If you are interested or have suggestions about what’s going on, keep in touch ! We’d love to hear about it!

You can find the original paper here. PLoS One is open access, so go ahead ad download it for free. It appears that this is the first materials science paper in PLoS One ? Filed in chemistry, though.

UPDATE 10/25/11 The CNRS issued a nice press release about our work. Check it out here.


October 17, 2011 § Leave a comment

aka table of contents, rolling on the floor laughing. This one is probably my favourite. Some outstanding graphical art out there. More seriously, check out the Nature Chemistry article here. Checking my RSS feed in the browser, or most of the time on the iPad with Reeder, graphical abstracts definitely helps identifying papers of interest (for me).

Too strange to be true

October 13, 2011 § Leave a comment

Check out the Nature paper on Shechtman’s nobel prize for his work on quasicrystals. I dig the idea in the commentaries:

we should have a separate section in journals for “too strange to be true” or something like that. That way, those who are experts and interested can evaluate it for themselves.


An extremely portable microscope

October 9, 2011 § 3 Comments

Love it.

We’ve also seen lots of physical additions to the iPhone camera. You can get wide-angle lenses, telephotos, and even a 12 xmicroscope lens. But a team of researchers at UC Davis has one-upped the competition by making the iPhone into a 350x microscope for very little money.

The original PLoS One paper is here. I am longing for an integration of something like ImageJ in the iPhone. You would end up with a terrific tool.


WolframAlpha to go mainstream … anonymously

October 5, 2011 § Leave a comment

This is the most interesting tidbit of yesterday’s apple news regarding the new iPhone, to me. WolframAlpha is now integrated into iOS. I hope OSX will follow, that would be quite something. The funny part is that people will be using it without even knowing it.

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